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Frontiers | Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patientsEctonucleotidases modulate inflammatory responses by balancing extracellular ATP and adenosine (ADO) and might be involved in COVID-19 immunopathogenesis. Here, we explored the contribution of extracellular nucleotides metabolism to COVID-19 severity in mild and severe cases of the disease. We verified that the gene expression of ectonucleotidases is reduced in the whole blood of patients with COVID-19 and is negatively correlated to CRP plasma levels, an inflammatory marker of disease severity. In line with these findings, COVID-19 patients present higher ATP levels in plasma and reduced levels of ADO when compared to healthy controls. Cell type-specific analysis revealed higher frequencies of CD39+ T cells in severely ill patients, while CD4+ and CD8+ expressing CD73 are reduced in this same group. The frequency of B cells CD39+CD73+ is also decreased during acute COVID-19. Interestingly, B cells from COVID-19 patients showed a reduced capacity to hydrolyze ATP into ADP and ADO. Furthermore, impaired expression of ADO receptors and a compromised activation of its signaling pathway is observed in COVID-19 patients. The presence of ADO in vitro, however, suppressed inflammatory responses triggered in patients’ cells. In summary, our findings support the idea that alterations in the metabolism of extracellular purines contribute to immune dysregulation during COVID-19, possibly favoring disease severity, and suggest that ADO may be a therapeutic approach for the disease.
Source: medical_xpress - 🏆 101. / 51 Read more »
For Some Families, COVID-19 Is Still Upending Holiday PlansEven as many people return to normal, some families are shaping their holiday 2022 plans around avoiding COVID-19 Mental illness Husband and I are staying home. Fully vaxed but had mild covid last week. Still testing positive w a sniffle! There would be 4 adults over 60 and one child under 5 present, and there is no way to socially distance a meal. So we're sitting this one out for everyone's good. We made it almost three years without getting it, now me, my husband, our 12 yo daughter, and both my parents all have COVID. No thanksgiving for us this year. Sucks.
Source: TIME - 🏆 93. / 53 Read more »
Town still waiting for 'vital' bus station retail units after three-years“The short answer is the covid pandemic put-paid to many business plans for two years'
Source: LiveLancs - 🏆 10. / 87 Read more »
UK car production returns to growth - but still below pre-COVID levelsThe number of cars produced for the UK market was up 12.5% and the number made for overseas was up 6.3%.
Source: SkyNews - 🏆 35. / 67 Read more »