Newly designed genetic therapy could alleviate debilitating giant moles in rare skin condition

The Francis Crick InstituteJun 17 2024 Research ers at the Francis Crick Institute, UCL Great Ormond Street Institute for Child Health and Great Ormond Street Hospital for Children have designed a new genetic therapy that could alleviate debilitating giant moles in a rare skin condition.

Published today in the Journal of Investigate Dermatology, the researchers silenced a gene called NRAS, which is mutated in the cells in these moles, in cells in a dish and in mice. NRAS belongs to a group of genes that, when mutated, can cause moles, and can predispose to cancer. Veronica Kinsler, Principal Group Leader of the Mosaicism and Precision Medicine Laboratory at the Crick, Professor of Paediatric Dermatology and Dermatogenetics at GOSH/UCL, and NIHR Research Professor, said: "CMN is physically and mentally challenging for children and adults living with this condition and for their families.

Source: Healthcare Press (healthcarepress.net)

Apoptosis Cancer Child Health Children Dermatology Gene Genes Genetic Hospital Melanoma Research RNA Skin Skin Cells Surgery Syndrome Womb

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