New stem cell transplant approach may expand donor pool for high-risk blood cancer patients

May 23 2024University of Miami Miller School of Medicine

Patients without an eligible family member often turn to the National Marrow Donor Program. The registry contains more than 40 million potential donors, but not everyone finds a match, particularly people from underrepresented racial and ethnic groups. Only about half of Hispanic and a quarter of Black patients can find a fully matched donor, compared with more than 70% of white patients.

City of Hope researcher Monzr Al Malki, M.D., will present the findings at ASCO. Jimenez Jimenez will present the data at the European Hematology Association annual congress in Madrid, June 14. Related StoriesCyclophosphamide counteracts a deadly side effect of transplantation called graft vs. host disease . In this condition, the transplant mounts an immune attack on the patient. The drug is thought to mitigate the effect of the cells that mediate GVHD.

In this initial phase of the study, the researchers examined data from 70 adult patients with advanced blood cancers. Patients received a "reduced-intensity" conditioning regimen to prepare them for transplantation, followed by stem cells from unrelated, partially matched donors. Donors had match levels from 4/8 to 7/8 on a one-to-eight scale, in which eight corresponds to a perfect match across eight key HLA markers. At match levels of 5/8 and above, more than 99% of people from a wide range of racial/ethnic groups are expected to find a donor.

Source: Education Headlines (educationheadlines.net)

Cell Research Bone Bone Marrow Cancer Cyclophosphamide Hematology Medicine Oncology Prophylaxis Stem Cells Transplant

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