New microfluidic device improves the separation of tumor cells and clusters from malignant effusions

Apr 13 2024Aerospace Information Research Institute, Chinese Academy of Sciences This novel technology promises to advance the diagnosis and treatment monitoring of cancer by enabling the high-throughput, continuous-flow ternary separation of single tumor cells, tumor cell clusters, and white blood cells from clinical pleural or abdominal effusions.

Understanding the nature of malignant effusions, teeming with tumor cells and clusters, is critical in comprehending the breadth of cancer's impact. The significant role of tumor clusters, with their heightened potential for metastasis compared to individual cells, cannot be overstated in the context of comprehensive cancer care.

In response to this challenge, a team of researchers from Southeast University has unveiled a microfluidic device, designed to achieve the precise separation of tumor entities with unprecedented efficiency. These findings were detailed in an article published on March 12, 2024, in Microsystems & Nanoengineering. This research introduces a device that skillfully integrates slanted spiral channels with periodic contraction-expansion arrays.

This design utilizes inertial forces to adeptly separate single tumor cells, tumor cell clusters, and WBCs from clinical samples of pleural or abdominal effusions-;key indicators of cancer metastasis. Operating at a brisk flow rate of 3500 µL/min, the device not only manages large volumes efficiently but also ensures an exceptionally high degree of separation accuracy.

Our device represents a substantial advancement in the analysis of malignant effusions. By efficiently isolating tumor cell clusters, known for their considerable metastatic potential, we're forging new pathways for the early detection and treatment of cancer." This innovation marks a significant milestone in the realm of cancer diagnostics, enhancing the efficiency and throughput of tumor cell and cluster separation from malignant effusions.

Cell Blood Cancer Diagnostics Diagnostics Malignant Metastasis Research Technology Tumor

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