Jun 5 2024Helmholtz Munich ) A recent study conducted by Helmholtz Munich and the German Center for Diabetes Research provides new insights into how fathers' diets and overweight can affect their children's health even before conception. The findings of the study can help develop preventive health measures for men wishing to become fathers: The healthier the father's diet, the lower the risk for their children to develop obesity or diseases such as diabetes later in life.
For their study, the researchers used data from the LIFE Child cohort, which includes information from over 3,000 families. The analyses showed that the father's body weight influences the weight of the children and their susceptibility to metabolic diseases. This influence exists independently from other factors such as the mother's weight, the parental genetics, or environmental conditions.
To deepen the findings, the research team conducted additional studies in the laboratory. They created embryos through in-vitro fertilization . When Teperino's team used sperm from mice that had been exposed to a high-fat diet, they found mt-tsRNAs from these sperm in early embryos, significantly influencing gene expression. This, in turn, affects the development and health of the offspring.
Source: Healthcare Press (healthcarepress.net)
Conception Diet Cell Diabetes DNA Epididymis Epigenetics Fertilization Gene Gene Expression Genetic Health Care Mitochondria Obesity Research RNA Sperm
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