By Pooja Toshniwal PahariaMay 23 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Environment International, researchers investigated the effect of per- and polyfluoroalkyl substances mixes on sperm methylome and transcriptional alterations in offspring metabolic organs .
About the study In the present study, researchers investigated the effects of preconception PFAS exposure in male mice on sperm epigenetics and offspring gene expression. Researchers conducted a follow-up study on adult male mice exposed to PFAS to investigate the intergenerational effects on their progeny. They collected caudal epididymal sperm and DNA from exposed and control animals, then used enzyme-linked immunosorbent assays to evaluate testosterone levels. They measured PFAS concentrations in the plasma, testes, and liver of F0 male mice.
Gene Expression Blood Carbohydrate Cell Cholesterol Cpg DNA Endocrine Estradiol Fertility Genes Hormone Illumina Liver Metabolism Muscle Sperm Testosterone
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