Monell study uncovers dual role of mammalian sweet taste receptor in regulating blood sugar levels

May 17 2024Monell Chemical Senses Center The rich research portfolio of the Monell Chemical Senses Center on sweet taste goes way back: Monell scientists were one of four teams in 2001 that found and described the mammalian sweet taste receptor – TAS1R2-TAS1R3. Twenty years later in 2021, a pair of papers published in Mammalian Genome by Monell researchers covered the genetics of sugar-loving mice.

Our objective was to determine whether TAS1R2-TAS1R3 influences glucose metabolism in two directions." "The novelty of our findings is that the receptor we studied in this experiment impacts blood glucose and insulin during a glucose meal differently, depending on whether it is stimulated or inhibited," said Breslin. This work provides further evidence that taste receptors help regulate metabolism and nutrient handling.

"This system is elegant in its simplicity," said Breslin. The same taste receptor is all over the body – the mouth, gastrointestinal tract, pancreas, liver, and fat cells, with the last three being major metabolic regulatory tissues, all part of the body's 24/7 metabolic watch.

Receptor Taste Receptor Agonist Blood Diabetes Food Genetics Genome Glucose Metabolism Insulin Metabolic Disorders Metabolic Syndrome Metabolism Pancreas Research Syndrome

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