Low rate of COVID-19 vaccination among high-risk pregnant women

By Dr. Liji Thomas, MDJul 17 2022Reviewed by Benedette Cuffari, M.Sc. Well into the third year of the coronavirus disease 2019 pandemic, novel vaccines against the severe acute respiratory syndrome coronavirus 2 continue to be developed. However, many groups and individuals remain hesitant about COVID-19 vaccination, including pregnant women who are at high risk for severe disease and adverse pregnancy outcomes.

Introduction The COVID-19 pandemic led to extensive and crippling waves of disease worldwide. This triggered the implementation of quarantine measures that ceased travel, business, education, and social interactions. Pregnant women who were at high risk for COVID-19, such as frontline medical and other workers, received COVID-19 vaccines early on in the pandemic. Observational studies have shown that no harm was caused to the mother nor fetus as a result of these vaccinations.

Study findings About 160 women participated in the current study, only about 33% of whom had received the vaccine. Of those who had not yet been vaccinated against COVID-19, most cited lack of information about the vaccine used in pregnancy as the reason for their unvaccinated status and feared adverse effects.

A history of influenza or tetanus-diphtheria pertussis vaccination also failed to show any correlation with COVID-19 acceptance rates. Interestingly, only a third of patients who received COVID-19 vaccines had taken the Tdap vaccine, whereas two-thirds of unvaccinated women had received this vaccine, though this difference failed to reach statistical significance.

Implications Vaccination rates among pregnant women continue to be low. It appears that a lack of trustworthy data regarding the safety of current COVID-19 vaccines in pregnancy is the primary obstacle.

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