LJI study details measles virus neutralization

La Jolla Institute for Immunology Jun 28 2024 Scientists in the La Jolla Institute for Immunology Center for Vaccine Innovation are working to develop new measles vaccines and therapeutics that stop this fusion process. The researchers recently harnessed an imaging technique called cryo- electron microscopy to show-;in unprecedented detail-;how a powerful antibody can neutralize the virus before it completes the fusion process.

What we learn about the fusion process can be medically relevant for Nipah, parainfluenza viruses, and Hendra virus. These are all viruses with pandemic potential." The urgent need for measles treatments Measles is a highly contagious, airborne disease that tends to strike children the hardest. Despite extensive vaccine efforts, the virus remains a major health threat. According to the World Health Organization and the U.S.

Related StoriesThere is no specific treatment for measles, so researchers are looking for antibodies to use as an emergency treatment to prevent severe disease. Membrane fusion, interrupted The LJI team needed to engineer a version of the measles fusion glycoprotein-;a harmless fragment of the virus-;stable enough to image with a cryo-electron microscope. To do this, Zyla worked closely with scientists in Porotto's laboratory at Columbia University.

"We got extremely good yields for the glycoprotein, which also enabled us to do structural biology and biochemical and biophysical studies," says Zyla. "It was striking to see what this intermediate step in the fusion process actually looks like," says Zyla.

Antibodies Antibody Cell Cell Membrane Children Electron Electron Microscopy Glycoprotein Imaging Immunology Membrane Microscopy Nipah Virus Pediatrics Ph Protein Research Structural Biology Therapeutics Vaccine Virus

United Kingdom Latest News, United Kingdom Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

New computational method developed for linking DNA marks to gene activity This Research, Pub...Scientists at La Jolla Institute for Immunology (LJI) have developed a new computational method for linking molecular marks on our DNA to gene activity.
Source: NewsMedical - 🏆 19. / 71 Read more »

New research points to 'stem-like' T cells as culprits in ulcerative colitisScientists at La Jolla Institute for Immunology (LJI) have shed light on how an unusual population of T cells may drive harmful inflammation in people with ulcerative colitis, an autoimmune disease that causes damage to the large intestine.
Source: medical_xpress - 🏆 101. / 51 Read more »

Study reveals how antibody mAb 77 neutralizes measles virusWhat happens when the measles virus meets a human cell? The viral machinery unfolds in just the right way to reveal key pieces that let it fuse itself into the host cell membrane.
Source: medical_xpress - 🏆 101. / 51 Read more »

New study warns of potential pandemic risk from α-H1N2 swine flu virusThe α-H1N2 influenza virus in swine poses a higher pandemic risk due to its ability to evade human immunity and transmit between species, highlighting the need for vigilant monitoring.
Source: NewsMedical - 🏆 19. / 71 Read more »

Study: Hepatitis E virus may be both sexually transmitted and linked to male infertilityDiscovering that hepatitis E virus is associated with sperm in pigs suggests the virus may be both sexually transmitted and linked to male infertility, according to a new study.
Source: NewsMedical - 🏆 19. / 71 Read more »

Infectious H5N1 influenza virus in raw milk rapidly declines with heat treatment, study showsThe amount of infectious H5N1 influenza viruses in raw milk rapidly declined with heat treatment in laboratory research conducted by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Source: medical_xpress - 🏆 101. / 51 Read more »