May 2 2024Weill Cornell Medicine The surprising findings could pave the way for therapeutic diets that may help ease symptoms and promote gut health.
Dietary fiber, including inulin, is considered an essential part of a healthy diet for most people. Gut microbes turn inulin and other types of dietary fiber into short-chain fatty acids that turn on immune cells called regulatory T cells, which help reduce inflammation and have other beneficial effects throughout the body.
Feeding inulin to mice in the context of a model of inflammatory bowel disease increased the production of certain bile acids by specific groups of gut bacteria. The increased bile acids boosted the production of an inflammatory protein called IL-5 by ILC2s. The ILC2s also failed to produce a tissue-protecting protein called amphiregulin.
Related StoriesThese unexpected discoveries may help explain why high-fiber diets often exacerbate inflammatory bowel disease in patients. It may also help scientists develop therapeutic diets to reduce symptoms and gut damage in patients with inflammatory bowel disease or related conditions. New therapies are urgently needed for these increasingly common gut conditions.
Source: Healthcare Press (healthcarepress.net)
Animal Model Bile Blood Diet Garlic Immune Response Immune System Inflammatory Bowel Disease Medicine Nutrition Preclinical Protein Research Supplements
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