Innovative plasma-activated hydrogel dressings revolutionize chronic wound care

Mar 13 2024University of Sheffield An effective treatment for chronic wounds that does not involve antibiotics, but an ionized gas to activate a wound dressing, has been developed by a team of international scientists.

Professor Rob Short, Professor of Chemistry at the University of Sheffield who co-authored the study, said: "More than 540 million people are living with diabetes worldwide, of which 30 per cent will develop a foot ulcer during their lifetime. This is a neglected global pandemic which is set to increase further in the coming years due to a rise in obesity and lack of exercise.

The cost of managing chronic wounds such as diabetic foot ulcers already exceeds $17 billion US dollars annually. "Growing resistance to antibiotics is a global challenge and there are also major concerns over silver-induced toxicity. In Europe, silver dressings are being phased out for this reason." Despite recent encouraging results in the use of plasma-activated hydrogel therapy , we faced the challenge of loading hydrogels with sufficient concentrations of RONS required for clinical use. We have overcome this hurdle by employing a new electrochemical method that enhances the hydrogel activation.

"A major advantage of our PAHT technology is that it can be used for treating all wounds. It is an environmentally safe treatment that uses the natural components in air and water to make its active ingredients, which degrade to non-toxic and biocompatible components."

Source: Healthcare Press (healthcarepress.net)

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