Mar 11 2024Karolinska Institutet The findings, published in Nature Cardiovascular Research, suggest that the response to the onset of atherosclerosis begins in the liver.
The liver responded immediately In the current study, researchers wanted to understand how different tissues in the body react to high levels of LDL, also called 'bad cholesterol', in the blood. To test this, they created a system where they could quickly increase the cholesterol in the blood of mice.
Stephen Malin, lead author of the study and principal researcher at the Department of Medicine, Solna, Karolinska Institutet "We were surprised to see that the liver seems to be the first line of defense against excess cholesterol and that the Kupffer cells were the ones doing the job," says Stephen Malin. "This shows that the liver immune system is an active player in regulating cholesterol levels, and suggests that atherosclerosis is a systemic disease that affects multiple organs and not just the arteries.
We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Key protein identified in protecting women from fatty liver diseaseNew research from Karolinska Institutet in Sweden shows how oestrogen protects against MASLD, a fatty liver disease that has increased dramatically during the current obesity epidemic.
Source: NewsMedical - 🏆 19. / 71 Read more »
Newborn T cells found to excel in immune defenseScientists have long believed that a newborn's immune system was an immature version of an adult's, but new research from Cornell University shows that newborns' T cells – white blood cells that protect from disease – outperform those of adults at fighting off numerous infections.
Source: NewsMedical - 🏆 19. / 71 Read more »
'Double life' of key immune protein reveals new strategies for treating cancer and autoimmune diseasesInsights into the workings of an immune cell surface receptor, called PD-1, reveal how treatments that restrict its action can potentially be strengthened to improve their anticancer effect, a new study shows.
Source: medical_xpress - 🏆 101. / 51 Read more »
Optimizing boosters: How COVID mRNA vaccines reshape immune memory after each dosemRNA vaccines developed against the spike glycoprotein of severe acute respiratory syndrome type 2 coronavirus (SARS-CoV-2), displayed remarkable efficiency in combating coronavirus 19 (COVID-19). These vaccines work by triggering both cellular and humoral immune responses against the spike protein of the virus.
Source: medical_xpress - 🏆 101. / 51 Read more »
Human whole blood for drug target discovery and immune response analysisHuman whole blood from BioIVT contains red and white cells as well as platelets suspended in plasma and can be used for various research applications, from drug target discovery to biomarker identification/validation and immune response analysis.
Source: NewsMedical - 🏆 19. / 71 Read more »
Study shows good sleep stimulates the immune systemResearchers at LMU Munich have shown that sleep enhances the migratory potential of T cells toward lymph nodes.
Source: medical_xpress - 🏆 101. / 51 Read more »