The six-legged mouse, right and the hind limbs develop from the same early structures. The team, led by developmental biologist Moisés Mallo, focused on one particular receptor protein, Tgfbr1. The protein, officially called transforming growth factor beta receptor I, is involved in the expression of genes – basically, helping decide which ones to activate where, deciding what each cell should become, for example, a blood cell, muscle tissue or a nerve cell.
It seems that, without this protein, other genes kicked into action, telling the cells to grow into legs rather than genitals. It wasn’t quite what the team was expecting. However, they now hope further research will enable them to determine whether Tgfbr1, and its relatives, can affect DNA in other systems – such as metastatic cancer.
Source: Healthcare Press (healthcarepress.net)
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