Gut dysbiosis and sepsis susceptibility among pregnant women

By Bhavana KunkalikarFeb 19 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Immunity, researchers in Brazil describe the crucial function of gut dysbiosis during pregnancy in promoting excessive macrophage pyroptosis, which increases vulnerability to sepsis.

Changes in the immunological response are likely responsible for the increased susceptibility and severity of infections that occur as pregnancy advances. However, the exact mechanisms responsible for the increased risk of sepsis during pregnancy remain uncertain. The potential role of gut dysbiosis during pregnancy in amplifying sepsis was assessed by transplanting fecal microbiota obtained from pregnant women or mice into non-pregnant mice. The team also conducted 16S ribosomal RNA gene sequencing to determine how gut microbial dysbiosis impacts sepsis susceptibility during pregnancy. A proteomic study was also performed.

Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Metabolomic analysis of cecum contents obtained from pregnant mice indicated a notable alteration in the metabolic characteristics of their gut microbiota, such as reduced formononetin levels. In addition, pregnant mice that had undergone CLP exhibited reduced Parabacteroides merdae levels in the peritoneal fluid lavage, which correlated with lower FMN concentrations.

Pregnancy or fecal microbiota transplantation from pregnant mice increased peritoneal macrophage cell mortality rates in mice with sepsis. In contrast, FMN therapy reduced the death of peritoneal macrophages. Furthermore, FMN lowered Nlrp3 messenger ribonucleic acid transcript among LPS/ATP-activated BMDM. This provided a novel mechanism by which FMN may regulate pyroptosis.

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