) that may cross into the CNS. It is therefore possible that circulating S1 or S1 protein fragments may cross the BBB and directly impair neurological activity, contributing to neurological symptoms observed in MIS-C and individuals recovering from COVID infections.
Another limitation is the nature of biological samples collected, which are mostly peripheral blood mononuclear cells and RNA isolated from whole blood, or plasma or sera, which do not allow to investigatemuti-system immune responses. Finally, there are technical difficulties in directly investigating if the SARS-CoV2 SAg-like motif binds to TCRs and MHC class II proteins and functionally acts as a SAg by activating T and B cells in ansystem.
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Antibodies in the breastmilk of COVID-19 recovered women - BMC Pregnancy and ChildbirthObjective Human milk contains antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which may serve as a protective factor through passive immunization in infants. The objective of this study was to measure the levels of anti-SARS-CoV-2 IgG and IgA in human milk and serum after a SARS-CoV-2 infection. Design Breast milk and serum samples from 72 lactating mothers with confirmed SARS-CoV-2 asymptomatic or symptomatic infection were collected 1-229 days after the onset of clinical symptoms related to COVID-19. Seventeen mothers with no history of COVID-19 served as a control group. Enzyme-Linked ImmunoSorbent Assay was performed to analyze antibodies against SARS-CoV-2. Results SARS-CoV-2-IgA human milk antibodies were detected in mothers and their concentrations were consistently higher than SARS-CoV-2-IgG antibodies. The serum and breastmilk samples of women with COVID-19 was characterized by a higher concentration of anti-RBD IgA and IgG than the serum from the control group without COVID-19. No statistically significant difference was observed between the antibody levels in the serum samples obtained from symptomatic and asymptomatic women exposed to SARS-CoV-2 and between the antibody level and the time from a positive SARS-CoV-2 test result over the period studied. Conclusion Our results confirm the presence of SARS-CoV-2 IgA and IgG antibodies in the breastmilk of COVID-19 recovered women and the possibility of these antibodies in providing specific immunologic benefits to breastfeeding infants such as protection against the virus transmission and severity of the acquired COVID-19 disease.
Source: BioMedCentral - 🏆 22. / 71 Read more »
SARS-CoV-2 prime and booster vaccinations found to improve pregnancy and birth outcomesResearchers evaluated the impact of coronavirus disease 2019 (COVID-19) prime vaccination and booster vaccination during pregnancy on maternal and fetal health outcomes.
Source: NewsMedical - 🏆 19. / 71 Read more »
Antibodies in the breastmilk of COVID-19 recovered women - BMC Pregnancy and ChildbirthObjective Human milk contains antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which may serve as a protective factor through passive immunization in infants. The objective of this study was to measure the levels of anti-SARS-CoV-2 IgG and IgA in human milk and serum after a SARS-CoV-2 infection. Design Breast milk and serum samples from 72 lactating mothers with confirmed SARS-CoV-2 asymptomatic or symptomatic infection were collected 1-229 days after the onset of clinical symptoms related to COVID-19. Seventeen mothers with no history of COVID-19 served as a control group. Enzyme-Linked ImmunoSorbent Assay was performed to analyze antibodies against SARS-CoV-2. Results SARS-CoV-2-IgA human milk antibodies were detected in mothers and their concentrations were consistently higher than SARS-CoV-2-IgG antibodies. The serum and breastmilk samples of women with COVID-19 was characterized by a higher concentration of anti-RBD IgA and IgG than the serum from the control group without COVID-19. No statistically significant difference was observed between the antibody levels in the serum samples obtained from symptomatic and asymptomatic women exposed to SARS-CoV-2 and between the antibody level and the time from a positive SARS-CoV-2 test result over the period studied. Conclusion Our results confirm the presence of SARS-CoV-2 IgA and IgG antibodies in the breastmilk of COVID-19 recovered women and the possibility of these antibodies in providing specific immunologic benefits to breastfeeding infants such as protection against the virus transmission and severity of the acquired COVID-19 disease.
Source: BioMedCentral - 🏆 22. / 71 Read more »
SARS-CoV-2 prime and booster vaccinations found to improve pregnancy and birth outcomesResearchers evaluated the impact of coronavirus disease 2019 (COVID-19) prime vaccination and booster vaccination during pregnancy on maternal and fetal health outcomes.
Source: NewsMedical - 🏆 19. / 71 Read more »