Cesar Franco was kept alive by machines after his lungs were badly damaged by Covid-19 complications Cesar Franco was left ‘shackled to life support’ machines by the illness but has been given a new lease of life by the drastic procedure.
But the father-of-one, from Streatham in south London deteriorated to the point where he had to be placed on a ventilator and life support machine at St Thomas’ hospital in central London. His surgeon described him as being a ‘prisoner in ICU’ before but is now recovering at home five months after being operated on.Mr Franco had not received a Covid-19 jab before he caught the virus but has since been vaccinated.‘I initially was hesitant when the doctors spoke to me about transplantation – I wanted my body to heal on its own, but it quickly became clear that this wasn’t an option for me, I was just so unwell.
He hopes to gradually return to his work as a maintenance engineer at a five-star hotel in the capital.
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Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines - Genome MedicineBackground COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially monocytes. However, little is known about the epigenetic alterations that occur in these cells during hyperinflammatory responses in severe COVID-19 patients. Methods In this study, we obtained the DNA methylome and transcriptome of peripheral blood monocytes from severe COVID-19 patients. DNA samples extracted from CD14 + CD15- monocytes of 48 severe COVID-19 patients and 11 healthy controls were hybridized on MethylationEPIC BeadChip arrays. In parallel, single-cell transcriptomics of 10 severe COVID-19 patients were generated. CellPhoneDB was used to infer changes in the crosstalk between monocytes and other immune cell types. Results We observed DNA methylation changes in CpG sites associated with interferon-related genes and genes associated with antigen presentation, concordant with gene expression changes. These changes significantly overlapped with those occurring in bacterial sepsis, although specific DNA methylation alterations in genes specific to viral infection were also identified. We also found these alterations to comprise some of the DNA methylation changes occurring during myeloid differentiation and under the influence of inflammatory cytokines. A progression of DNA methylation alterations in relation to the Sequential Organ Failure Assessment (SOFA) score was found to be related to interferon-related genes and T-helper 1 cell cytokine production. CellPhoneDB analysis of the single-cell transcriptomes of other immune cell types suggested the existence of altered crosstalk between monocytes and other cell types like NK cells and regulatory T cells. Conclusion Our findings show the occurrence of an epigenetic and transcriptional reprogramming of peripheral blood monocytes, which could be associated with the
Source: BioMedCentral - 🏆 22. / 71 Read more »
How our High Streets changed over the Covid lockdownsThere are fewer banks and shops but beauty parlours have prospered, BBC analysis of data has found.
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COVID testing requirements scrapped in Beijing as China starts to relax measuresOfficials have been playing down the dangers the virus poses, bringing China in closer alignment with what other countries have been saying for more than a year as they opted to live with the virus and drop restrictions. How many brave, strong people have been carted away. Depleting the Chinese people of true leadership and innovation. Take notes UK scrap it All I keep seeing in twitter is people being rounded up and out into covid camps
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Telford girl, 11, who was severely ill with Covid complications wants to help other poorly childrenAn 11-year-old who was severely ill with complications from Covid has decided that she wants to help other poorly children by having her long hair cut to make a wig.
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Can China escape zero-covid?Our weekly podcast on China. This week, how China’s zero-covid policy turned from a triumphant success that saved lives into a trap with big human and economic costs DSORennie aliceysu Does China care too much about public health? Should China really chill about making sure as few people as possible get sick with covid? Is China stuck on caring about citizens? That's how this sounds🙄 DSORennie aliceysu DSORennie aliceysu What I liked about the first few episodes of Drum Tower: it went deep into the weeds of the topic from the get go. It seemed to assume that the listener already had some basic knowledge of China. I hope they keep this up. No point in repeating basic facts we hear everywhere. 👍
Source: TheEconomist - 🏆 6. / 92 Read more »