Early feasibility studies on climate-friendly albuterol inhaler completed

May 11 2024Bespak DevPro Biopharma and Bespak have announced the completion of early feasibility studies on DP007, a new formulation of albuterol in a pressurized metered dose inhaler which shows comparable performance to Ventolin® HFA but with a significant reduction in greenhouse gas emissions.

The new formulation has the potential to revolutionize the treatment of respiratory disease by reducing the global warming potential impact of albuterol inhalers such as Ventolin, the most commonly prescribed inhaler type globally. It is expected to be commercialized by mid-2027 to meet the requirements of the US phasedown of fluorinated gases under the American Innovation and Manufacturing Act of 2020.

The innovative formulation is being developed by Bespak at its Research Triangle Park, NC research facility under the terms of an exclusive agreement with DevPro Biopharma. The new formulation contains Honeywell’s Solstice® Air cGMP), a hydrofluoroolefin propellant that has 99.9% less global warming potential than current HFAs and is in clinical development for pMDI products.

for albuterol pMDIs producing emissions equivalent to more than 200,000 passenger vehicles. There is an urgent need to develop a low-GWP albuterol pMDI to reduce the environmental impact of the life-saving inhalers patients need, without sacrificing performance or ease-of-use. Working with Bespak, we are excited about the results we have seen with DP007 showing comparable performance with Ventolin HFA.

Manufacturing Research Respiratory

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