]. They had relatively mild respiratory symptoms which brought them to George Washington University Outpatient Clinic or Hospital for COVID-19 testing, and none required oxygen therapy, hospitalization or assisted ventilation. Each patient was interviewed by Telehealth video linkage, and self-reported neurological complaints including details of their cognitive ability, and other neurologic symptoms, as well as the degree to which their symptoms were affecting their quality of life.
Patients self-reported an average of 4 neurological complaints, the most common being cognitive impairment, which could be described as poor memory or concentration, mental confusion or “brain fog” , followed by fatigue , new onset headache , word finding or speech impairment , altered sense of smell or taste , myalgia , paresthesia , new anxiety or depression , sleep disorder , and dizziness or vertigo .
On standard Brain MRI using conventional 3 Tesla Siemens scanners, one patient had a small pituitary microadenoma, while 3 of the older study patients had nonspecific white matter changes attributed to “microvascular ischemic change”. Microvascular ischemic changes are commonly seen due to aging and are not associated with a particular symptomatic profile. None of the remaining 20 study patients had structural abnormalities on standard Brain 3 T MRI.
Table 1 Patient Characteristics with NeuroQuant processing evaluates brain volumes as intracranial percentiles compared to normal controlsAn example of NeuroQuant® numeric data acquisition and 3-dimensional voxel-based morphometry results in patient #7 is provided in Fig.which tracks volumes of thalamus, hippocampus and cortical grey matter as their percentage of total intracranial volume when compared with normative database drawn from healthy controls and adjusted for age, and sex.
Source: Healthcare Press (healthcarepress.net)
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