Common brain network detected among people with substance use disorder

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A new study by researchers at Brigham and Women's Hospital suggests a common brain network exists among people with substance use disorder. By evaluating data from across more than 144 studies of addiction, the team found abnormalities across substance use disorders mapped to a common brain network across substances and lesion locations, suggesting a potential brain circuit to target with neurostimulation therapies. The findings are published in Nature Mental Health.

regions implicated in addiction are all a part of a common brain circuit," said Michael Fox, MD, Ph.D., a corresponding author on the paper and founding director of the Center for Brain Circuit Therapeutics at Brigham and Women's Hospital."Consistency across different papers means we now have a brain circuit to target addiction with treatments, rather than just a region."

The team looked at data from previous studies involving more than 9,000 participants. Within each of those studies, different brain regions were noted as a place to target to treat addiction. Researchers used a network mapping approach with an average wiring diagram to find the link between the different types of brain imaging lesions that affect addiction. It also looked at different substances and found the network was common, whether someone was addicted to nicotine, alcohol, cocaine or heroin.substance use disorder

 

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