Beyond exhaustion: study identifies fatigue as key factor limiting functionality in long COVID patients

By Pooja Toshniwal PahariaJun 13 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in BMJ Open, researchers assess self-documented post-coronavirus disease 2019 syndrome or long COVID symptoms among care-seeking individuals. The impact of PCS symptoms on work abilities and health-related quality of life was also determined.

In the present cross-sectional observational study, researchers present the baseline symptomatology and functional impairments among treatment-seeking long COVID patients and reported different patient-documented symptoms that contributed to these impairments. The five-item Perceived Deficits Questionnaire was used to assess cognitive impairments, whereas the Medical Research Council Dyspnea Scale and Dyspnoea-12 questionnaire were used to evaluate breathlessness. HR-QoL was evaluated using the EQ-5D, which measures self-care, mobility, routine activities, discomfort or pain, and depression or anxiety.

Study findings Among the study participants, 94% were between 18 and 65 years of age, with a mean participant age of 48. Moreover, 71% of the study cohort were women, 87% were White, and 53% had attained degree-level education. Fifty-one percent of the study participants lost one or more work days in the preceding four weeks, whereas 20% could not resume work.

The mean EQ-5D score was 0.6, with the discomfort/pain and depression/anxiety domains most affected, and the mean FACIT-F score was 19.60. The mean GAD-7, PHQ-8, Dyspnoea-12, and PDQ-5 scores were 9.0, 11.80, 12, and 12, respectively. Among the study participants, the median MRC Dyspnoea Scale score was two.

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