The battle to avoid finishing last starts the day off as Italy take a trip to Wales, followed by Ireland hosting Scotland in Dublin where victory would seal successive Six Nations triumphs for the Irish.
However, dominant wins in each of their previous three fixtures will give Ireland all the required confidence to claim the title against Scotland, whose own title ambitions were ended by a 31-29 defeat in Italy last time out. Duhan Van der Merwe and Blair Kinghorn can cause havoc from the back - as they have on a multitude of occasions this year - however Scotland have historically struggled in Ireland, with their last victory over the Irish Sea coming in 2010.
Wales have lost each of their four fixtures so far, with heavy defeats to France and Ireland undoing the promising work shown in tight losses to Scotland and England in the opening weeks.
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