By Roland SebestyenA footbridge in South Yorkshire which had to be removed after damage by vandals has been replaced.Councillor James Higginbottom said replacing the bridge had been delayed by difficulties finding a contractor.
Residents had been "hugely frustrated" by the emergency closure and the subsequent delay in work starting on a new structure, Mr Higginbottom said.: "I am very pleased to report that the replacement bridge over Lundhill Canal has now been installed and is open to the public."This is a hugely positive development and means that residents can access the canal paths for walking and cycling once again.
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Total choline intake and working memory performance in adults with phenylketonuria - Orphanet Journal of Rare DiseasesBackground Despite early diagnosis and compliance with phenylalanine (Phe)-restricted diets, many individuals with phenylketonuria (PKU) still exhibit neurological changes and experience deficits in working memory and other executive functions. Suboptimal choline intake may contribute to these impairments, but this relationship has not been previously investigated in PKU. The objective of this study was to determine if choline intake is correlated with working memory performance, and if this relationship is modified by diagnosis and metabolic control. Methods This was a cross-sectional study that included 40 adults with PKU and 40 demographically matched healthy adults. Web-based neurocognitive tests were used to assess working memory performance and 3-day dietary records were collected to evaluate nutrient intake. Recent and historical blood Phe concentrations were collected as measures of metabolic control. Results Working memory performance was 0.32 z-scores (95% CI 0.06, 0.58) lower, on average, in participants with PKU compared to participants without PKU, and this difference was not modified by total choline intake (F[1,75] = 0.85, p = 0.36). However, in a subgroup with complete historical blood Phe data, increased total choline intake was related to improved working memory outcomes among participants with well controlled PKU (Phe = 360 µmol/L) after adjusting for intellectual ability and mid-childhood Phe concentrations (average change in working memory per 100 mg change in choline = 0.11; 95% CI 0.02, 0.20; p = 0.02). There also was a trend, albeit nonsignificant (p = 0.10), for this association to be attenuated with increased Phe concentrations. Conclusions Clinical monitoring of choline intake is essential for all individuals with PKU but may have important implications for working memory functioning among patients with good metabolic control. Results from this study should be confirmed in a larger controlled trial in people living with PKU.
Source: BioMedCentral - 🏆 22. / 71 Read more »
Wrexham's reality check, QPR in danger and Barnsley ones to watchThe English Football League was back with a bang this weekend, and there was plenty to learn from the opening fixtures. Southampton and Sheffield Wednesday raised the curtain on the 2023/24 Champio…
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Boost your probiotic intake with Korean tofu and buttered kimchiTofu is an excellent source of plant-based protein (great for muscle repair and energy), making this dish a great one to consume before or after a workout.
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Urinal appears on the side of Sonning bridge over River ThamesThe same Sonning bridge has seen previous additions including a post box, front door and telephone.
Source: BBCNews - 🏆 3. / 97 Read more »
The beautiful Yorkshire village that's frozen in time a short drive awayThe beautiful Yorkshire village that's frozen in time and just a 40 minute drive from Greater Manchester
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Ukraine war: Another Russian vessel hit by sea drone near Crimean Bridge, Moscow saysThe targeted tanker, its operator and its owner had previously been sanctioned by the US for its role in delivering jet fuel to Russian troops in Syria.
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