Bariatric surgery may protect against development of breast cancer in women with obesity

By Vijay Kumar MalesuMay 20 2024Reviewed by Danielle Ellis, B.Sc. In a recent study published in the JAMA Surgery, a group of researchers investigated the association between bariatric surgery and breast cancer incidence in women and determined if baseline insulin levels influence the benefit of bariatric surgery on breast cancer risk.

About the study The present Swedish Obese Subjects study enrolled 4,047 participants with obesity, aged 37 to 60 years, with a body mass index of 34 or greater for men and 38 or greater for women. Participants were recruited in Sweden from 1987 to 2001. The surgery group included 2010 participants undergoing various bariatric procedures, while a matched control group of 2037 participants received usual care.

Study results The study population consisted of 2,867 women with a mean age of 48.0 years. Baseline characteristics of the surgery group and the usual care group showed significant differences in 12 out of 17 characteristics. A higher proportion of women in the usual care group were menopausal at baseline compared to the surgery group .

There were no significant differences in BMI during follow-up among participants with and without breast cancer diagnoses within the treatment groups. Stratifying by menopausal status at baseline, breast cancer incidence was higher in the usual care group than in the surgery group after adjustment for premenopausal women but not for postmenopausal women .

Source: Healthcare Press (healthcarepress.net)

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