Daryl had been freelancing for 3 years before joining TechRadar, now reporting on everything software-related. In his spare time he's written a book, 'The Making of Tomb Raider', alongside podcasting and usually found playing games old and new on his PC and MacBook Pro.
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Horror as teens poisoned at summer camp after they complained of feeling 'dizzy'MORE than a dozen people were poisoned by carbon monoxide at a Long Island summer camp after they complained of feeling sick and dizzy. Emergency services raced to the scene at the Chabad of Great …
Source: TheSun - 🏆 64. / 61 Read more »
How to start Monster Hunter Rise: SunbreakNow that Sunbreak has released, here's what you need to finish quest-wise to start playing
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Novel mitochondria-targeting compounds selectively kill human leukemia cells - LeukemiaLeukemia - Novel mitochondria-targeting compounds selectively kill human leukemia cells RiceUniversity pregnancy bloodcancer pediatrics cancer AML leukemia bonemarrow DNA stemcells Ethical healthscience monitors and improves sunlight exposure (UVB, UVA, blue, red, infrared) and nocturnal melatonin amplitude and volume during prenatal development and throughout life. . RiceUniversity leukemia AML bloodcancer cadmium sustainability Sustainable healthcare includes comprehensive human biomonitoring of toxic metals, phthalates, bisphenol A/F/S, PFOS, arsenic and other harmful chemicals as part of preconception, prenatal and general preventive healthcare. .
Source: medical_xpress - 🏆 101. / 51 Read more »
Ceritinib is a novel triple negative breast cancer therapeutic agent - Molecular CancerBackground Triple-negative breast cancers (TNBCs) are clinically aggressive subtypes of breast cancer. TNBC is difficult to treat with targeted agents due to the lack of commonly targeted therapies within this subtype. Androgen receptor (AR) has been detected in 12–55% of TNBCs. AR stimulates breast tumor growth in the absence of estrogen receptor (ER), and it has become an emerging molecular target in TNBC treatment. Methods Ceritinib is a small molecule inhibitor of tyrosine kinase and it is used in the therapy of non-small lung cancer patients. Enzalutamide is a small molecule compound targeting the androgen receptor and it is used to treat prostate cancer. Combination therapy of these drugs were investigated using AR positive breast cancer mouse xenograft models. Also, combination treatment of ceritinib and paclitaxel investigated using AR− and AR low mouse xenograft and patient derived xenograft models. Results We screened 133 FDA approved drugs that have a therapeutic effect of AR+ TNBC cells. From the screen, we identified two drugs, ceritinib and crizotinib. Since ceritinib has a well- defined role in androgen independent AR signaling pathways, we further investigated the effect of ceritinib. Ceritinib treatment inhibited RTK/ACK/AR pathway and other downstream pathways in AR+ TNBC cells. The combination of ceritinib and enzalutamide showed a robust inhibitory effect on cell growth of AR+ TNBC cells in vitro and in vivo. Interestingly Ceritinib inhibits FAK-YB-1 signaling pathway that leads to paclitaxel resistance in all types of TNBC cells. The combination of paclitaxel and ceritinib showed drastic inhibition of tumor growth compared to a single drug alone. Conclusions To improve the response of AR antagonist in AR positive TNBC, we designed a novel combinational strategy comprised of enzalutamide and ceritinib to treat AR+ TNBC tumors through the dual blockade of androgen-dependent and androgen-independent AR signaling pathways. Furthermore, we introduced LSU TNBC circadian rhythm healthequity breastcancer The risk of triple negative breast cancer (TNBC) is reduced by preventive healthcare that measures the diurnal cortisol rhythm and nocturnal melatonin amplitude and volume. .
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Novel gene for Alzheimer's disease in women identifiedAlzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S. Scientists have discovered some genetic variants that increase the risk for developing Alzheimer's; the most well-known of these for people over the age of 65 is the APOE ε4 allele. Approximately 60 percent of people from European ancestry with Alzheimer's carry this genetic variant, compared to just 26 percent of the general population, implying that other genes contribute to the genetic makeup of the disease.
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7 reasons to try Strava — boost your rides by bagging segmentsWhy the ride-recording and segment-racing app should be part of your riding
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