Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women - Genome Medicine

). This study conformed to the principles of the Helsinki Declaration. The trial was prospectively registered, and the date of first patient enrolment was 24 November 2009; the last subject was screened in November 2013 and the last study contact was in January 2015. Data were collected at the Karolinska University Hospital, Stockholm, Sweden. Mifepristone was obtained from Exelgyn, Paris, France, and visually indistinguishable vitamin B from Recip, Stockholm, Sweden.

From Clinical Trial 1, 12 women from each of the vitamin and mifepristone groups were included in this study; of these, 11 and 9 women, respectively, had provided sufficient DNA from the pre- and post-treatment biopsies for subsequent processing and analysis. In addition, 15 women from the mifepristone group were also used to extract RNA and subsequent downstream processing and analysis were performed to check RANKL expression and cell type proportion analysis.

” . This study conformed to the principles of the Helsinki Declaration. This trial was prospectively registered, the first patient was consented in March 2016 and the last in March 2019. The main data collection took place at Manchester University NHS Foundation Trust, Manchester, U.K. Commercially available ulipristal acetate 5 mg tablets were administered.

Source: Healthcare Press (healthcarepress.net)

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