Apple enthusiasts with cash to spare will have until February 19 to bid on the precious piece of tech history American Tattoo artist, Karen Green, who was gifted the 8 GB version of the phone and never broke the seal is set to make bank by auctioning the tech relic.
The first generation iPhone was the model originally revealed by Apple co-founder Steve Jobs in 2007 Apple enthusiasts with cash to spare will have until February 19 to bid on the precious piece of tech history. When Jobs first revealed the device fifteen years ago, he called it a combination of ‘an iPod, a phone, and an internet communicator’.
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Pressure mounts on Bank of England as US interest rate hiked to highest since 2007The Bank of England is anxious to avoid pushing the UK into a recession by raising borrowing costs, but its mandate is to keep inflation at around 2 per cent Taking more from mortgage payers to ease inflation is nuts, many don’t have any disposable cash already and further rises will only cripple the housing market and cause many to lose their homes, we are all paying for the rich to maintain their wealth.
Source: i newspaper - 🏆 8. / 89 Read more »
Efficacy, safety, and tolerability of antidepressants for pain in adults: overview of systematic reviewsObjective To provide a comprehensive overview of the efficacy, safety, and tolerability of antidepressants for pain according to condition. Design Overview of systematic reviews. Data sources PubMed, Embase, PsycINFO, and the Cochrane Central Register of Controlled Trials from inception to 20 June 2022. Eligibility criteria for selecting studies Systematic reviews comparing any antidepressant with placebo for any pain condition in adults. Data extraction and synthesis Two reviewers independently extracted data. The main outcome measure was pain; for headache disorders it was frequency of headaches. Continuous pain outcomes were converted into a scale of 0 (no pain) to 100 (worst pain) and were presented as mean differences (95% confidence intervals). Dichotomous outcomes were presented as risk ratios (95% confidence intervals). Data were extracted from the time point closest to the end of treatment. When end of treatment was too variable across trials in a review, data were extracted from the outcome or time point with the largest number of trials and participants. Secondary outcomes were safety and tolerability (withdrawals because of adverse events). Findings were classified from each comparison as efficacious, not efficacious, or inconclusive. Certainty of evidence was assessed with the grading of recommendations assessment, development, and evaluation framework. Results 26 reviews (156 unique trials and |25 000 participants) were included. These reviews reported on the efficacy of eight antidepressant classes covering 22 pain conditions (42 distinct comparisons). No review provided high certainty evidence on the efficacy of antidepressants for pain for any condition. 11 comparisons (nine conditions) were found where antidepressants were efficacious, four with moderate certainty evidence: serotonin-norepinephrine reuptake inhibitors (SNRIs) for back pain (mean difference −5.3, 95% confidence interval −7.3 to −3.3), postoperative pain (−7.3, −12.9 to −1.7), neurop bmj_latest What’s about anticonvulsants (e.g. pregabaline)? bmj_latest What’s about anticonvulsants (e.g. pregabaline)?
Source: medical_xpress - 🏆 101. / 51 Read more »
Pressure mounts on Bank of England as US interest rate hiked to highest since 2007The Bank of England is anxious to avoid pushing the UK into a recession by raising borrowing costs, but its mandate is to keep inflation at around 2 per cent Taking more from mortgage payers to ease inflation is nuts, many don’t have any disposable cash already and further rises will only cripple the housing market and cause many to lose their homes, we are all paying for the rich to maintain their wealth.
Source: i newspaper - 🏆 8. / 89 Read more »
Steven Bartlett: Firm founded by Dragons' Den star to sell for £7.7mSocial media agency Social Chain, founded by Steven Bartlett in Manchester, is set to be sold. Good for him but he’s still a bellend blimey ! he's done well ! love his necklace too ! And🤔
Source: BBCNews - 🏆 3. / 97 Read more »
It Takes Two leaps past ten million copies soldHazelight's co-op platformer It Takes Two has reportedly been a roaring success for the studio — it has just announced that the popular two-player adventure has passed the ten million copies sold milestone. One of the best, recent co-op experiences that I have played. Amazing gameplay. TattooedViking_ 👀 So that's essentially 20mil as they give away friend copy with each purchase. That's a tremendous success for a niche co-op only genre game.
Source: TrueAchievement - 🏆 31. / 68 Read more »
Final slice of Langholm Moor sold to conservation firmOne of Scotland's biggest landowners has agreed the sale of thousands of acres near Langholm.
Source: BBCScienceNews - 🏆 87. / 53 Read more »