Agitated Nutsche Filter Dryer (ANFD) Systems: Harnessing the Potential of HPAPI Development and Manufacturing

Sponsored Content by Powder SystemsMay 22 2024Reviewed by Andrea Salazar Highly potent active pharmaceutical ingredients are increasingly in demand, particularly in areas of precision medicine and anti-cancer therapeutics. These small molecules and biologics serve as the foundation for a range of innovative drug products, such as antibody-drug conjugates and emerging drug substances aimed at treating autoimmune diseases.

Rigid Double Chamber Discharge Isolator for low nanogram containment performance. Image Credit: Powder SystemsUnderstanding ANFD containment ANFD systems are present throughout the HPAPI pipeline, including intermediate and final product manufacturing. In either scenario, products with high-toxicity payloads are discharged from a plug and must be effectively contained, either prior to being looped back to an earlier phase of development or being filled into packaging containers.

For HPAPI containment, a single chamber glove box with a negative pressure environment and additional safety features can be suitable. However, there are further considerations to make in addition to physical isolation and air management. It is imperative to minimize initial sources of contamination, emphasizing containment and air management around the discharge plug as a priority. However, equipment manufacturers must also anticipate critical process parameters to ensure the containment system operates effectively.

Powder Systems Limited has designed ANFD solutions with enclosures suitable for the most potent drugs in development. PSL can anticipate crucial features that improve the filter drying process from both a performance and regulatory perspective.

ANFD HPAPI

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