May 20 2024NIH/National Heart , Lung and Blood Institute A National Institutes of Health -supported clinical trial has found that intravenous acetaminophen reduced sepsis patients' risk of having organ injury or developing acute respiratory distress syndrome , a serious condition that allows fluid to leak into the lungs. Sepsis is the body's uncontrolled and extreme response to an infection.
Scientists note that identifying high levels of cell-free hemoglobin as a biomarker that could be tested when patients are first admitted to the hospital would be a breakthrough, because it could help quickly determine which patients with sepsis might benefit from acetaminophen therapy. Michael Matthay, M.D., professor of medicine and anesthesia, University of California, San Francisco, and senior study author
The researchers found that intravenous acetaminophen was safe for all the sepsis patients, with no difference in liver injury, low blood pressure, or other adverse events compared to the placebo group. Among secondary outcomes, they also found that organ injury was significantly lower in the acetaminophen group, as was the rate of acute respiratory distress syndrome onset within seven days of hospital admission.
Source: Healthcare Press (healthcarepress.net)
Acute Respiratory Distress Syndrome Respiratory Sepsis Syndrome Biomarker Blood Cell Clinical Trial Critical Care Heart Hemoglobin Hospital Lungs Medical Research Medicine Mortality Pain Placebo Red Blood Cells Research
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