]. In the ancient metagenomics and paleopathology fields, NTM are usually mentioned within environmental contexts or as contaminants, due to the difficulty to confidently assign them as true pathogens likeHowever, in this study, we opted to extensively analyze the genome of the brain NTM to explain their unusual existence and high abundance in the brain. The primary approach to check the DNA of a genome of whether it is ancient, is to analyze the ancient DNA damage pattern, i.e.
In our case, the NTM contamination possibility can be toned down as soon as we consider the following: the extraordinarily high abundance in the brain; the exclusive incidence in the brain and the close-by tissues and the absence from the other control samples as well as other organs of the mummy; the distribution of the putative phage within the mummy’s tissues and the absence from the control samples; the virulence potential of the genome particularly including genes that can enable crossing...
Overall, and based on the radiological, histological, toxicological, and molecular analyses of the ACB’s mummy, the current situation might suggest two different scenarios that explain her health status in relation to the high mercury concentrations. First, ACB suffered from syphilis and was exposed to a mercury treatment successfully, andwas completely eradicated, while the NTM brain infection occurred later.
Source: Healthcare Press (healthcarepress.net)
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