WASHINGTON: The gene edits given to Chinese twins last year meant to immunise them against HIV may have failed in its purpose and created unintended mutations, scientists said on Tuesday after the original research was made public for the first time.
A small percentage of people are born with immunity because of a mutation in a gene called CCR5 and it was this gene that He had claimed he had targeted using a powerful editing tool known as CRISPR which has revolutionised the field since bursting on the scene in 2012. Moreover, CRISPR remains an imperfect tool because it can lead to unwanted or"off-target" edits, making its use in humans hugely controversial.
Further ethical concerns included that the parents of the babies might have wanted to take part for the wrong reasons.
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