WASHINGTON - The gene edits given to Chinese twins last year meant to immunise them against HIV may have failed in its purpose and created unintended mutations, scientists said on Tuesday , after the original research was made public for the first time.
A small percentage of people are born with immunity because of a mutation in a gene called CCR5 and it was this gene that He had claimed he had targeted using a powerful editing tool known as Crispr which has revolutionised the field since bursting on the scene in 2012. Here, the researchers claimed they had searched for such effects in the early-stage embryos and found just one - but this glossed over the fact that it would be impossible to carry out a comprehensive search without inspecting each of the embryo's cells and thus destroying it.
‘Birth of Twins After Genome Editing for HIV Resistance’
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