Pfizer, BioNTech say Omicron-based COVID shots improve response vs that variant

25/06/2022 5:35:00 PM

The shots are well-tolerated in participants, the companies say

Covıd-19 Vaccines, Life &Amp

The shots are well-tolerated in participants, the companies say.

The shots are well-tolerated in participants, the companies say

Advisors to the US Food and Drug Administration are scheduled to meet on Tuesday, June 28, to discuss whether to update COVID-19 vaccines for the fall. Theupdated shotsare likely to be redesigned to combat the Omicron variant of the coronavirus, experts say.

Pfizer and BioNTech said that 30 and 60 microgram doses of a shot targeting just the BA.1 Omicron subvariant that was circulating last winter elicited a 13.5 and 19.6-fold increase in neutralizing geometric titers against that subvariant. A version of the shot that contained both the redesigned vaccine and their original vaccine elicited a 9.1 and 10.9-fold increase, they said.

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NEW YORK, USA – Pfizer and BioNTech SE said on Saturday, June 25, that a booster dose of updated versions of their COVID-19 vaccine, modified specifically to combat the Omicron coronavirus variant, generated a higher immune response against that variant.Analou de Vera Coronavirus vaccines have been prepared for distribution at a vaccination site in Manila on May 18, 2021.Face masks had been compulsory in public since mid-2021, when the country saw a wave of cases driven by the spread of the Delta variant.The study, published in The Lancet Infectious Diseases, is based on data from 185 countries and territories collected from December 8, 2020 to December 8, 2021.

Advisors to the US Food and Drug Administration are scheduled to meet on Tuesday, June 28, to discuss whether to update COVID-19 vaccines for the fall. The updated shots are likely to be redesigned to combat the Omicron variant of the coronavirus, experts say. The DOH reiterated that this policy is in accordance with the recommendation of the Health Technology Assessment Council (HTAC). Pfizer and BioNTech said that 30 and 60 microgram doses of a shot targeting just the BA. The health ministry recommends people continue to wear face masks in crowded or poorly ventilated areas, the statement added, but there was no explicit mention of public transport.1 Omicron subvariant that was circulating last winter elicited a 13. “Healthcare workers are given the second booster in consideration of their high risk exposures to patients,” it added.5 and 19. It was a 63 percent reduction, the study found.

6-fold increase in neutralizing geometric titers against that subvariant.” “Only one out of five Filipinos eligible for a first booster (around 14. "The lifting (of restrictions) would allow people to resume their normal life," said Supanya Pajaree, a 26-year-old freelance worker. A version of the shot that contained both the redesigned vaccine and their original vaccine elicited a 9.1 and 10. “DOH invites our private sector partners to please help get the jab done by encouraging all employees, store owners, and others to get their first booster,” it added.9-fold increase, they said. The Thai government's move comes after Singapore and Cambodia also discarded rules requiring outdoor mask wearing. The results were from a trial of 1,234 people aged 56 or older.  China was not included in the study because of its large population and strict containment measures, which would have skewed the results, it said.

The shots were well-tolerated in participants, the companies said. They said that early laboratory studies suggest that both Omicron-modified candidates neutralize the Omicron BA. Thailand's economy has faltered in the last two years, with growth hammered by the bitter combination of rising living costs and Covid-19.4 and BA.5 subvariants that have been circulating more recently, though to a lesser extent than they do for BA.1, with titers approximately 3-fold lower. In the first six months of 2019 that figure was just under 20 million, the data showed.  "Millions of lives have probably been saved by making vaccines available to people around the world," said lead study author Oliver Watson of Imperial College London.

 The companies say they are continuing to collect data on how well the boosters perform versus the more recently circulating strains. Moderna Inc MRNA.O has also made a redesigned vaccine targeting the BA. —Agence France-Presse Tags:.1 Omicron subvariant. The company said its updated vaccine worked well against more recent Omicron subvariants, and that it was moving forward with plans to ask regulators for approval. The figures are extremely sensitive due to how they reflect on the handling of the crisis by authorities around the world.

– Rappler.com .