New research further supports a role for inflammation in the development of psychiatric disorders, in findings that may aid in the early identification of individuals at high risk.
New research provides more evidence that inflammation may contribute to the development of psychiatric disorders and suggests that measuring certain inflammatory biomarkers may aid in the early identification of individuals at high risk.
In addition, a higher level of leukocytes was consistently associated with increased odds of depression across different methods of mendelian randomization analysis,"indicating a possible causal relationship between leukocytes and depression," they said. In the AMORIS cohort, individuals with a higher than median level of leukocytes , haptoglobin , or CRP had an elevated risk for any psychiatric disorder. In contrast, there was an inverse association for IgG level .
"Possible explanations mainly include blood-brain barrier disruption, microglia activation, neurotransmission impairment, and other interactions between inflammations and neuropathology," the researchers wrote. "Eventually the field will want to embrace this novel phenotype and better understand how to recognize it and treat it. This is our entrée into precision psychiatry where we identify the right treatment for the right patient at the right time based on an understanding of the underlying cause of their illness," Miller added.
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