US biotech firm Moderna’s COVID-19 vaccine induced a robust immune response and prevented the coronavirus from replicating in the noses and lungs of monkeys, a study in the New England Journal of Medicine said Tuesday.
In the Moderna animal study, three groups of eight rhesus macaques received either a placebo or the vaccine at two different dose levels -- 10 micrograms and 100 micrograms. The authors reported that the vaccine also induced the production of a different immune cell known as T-cells that may have helped boost the overall response.
Four weeks after the monkeys received their second injection, they were exposed to the SARS-CoV-2 virus, both through the nose and directly to the lungs via a tube. A COVID-19 vaccine capable of stopping the virus in the lungs will prevent the disease from becoming severe, while stopping the virus from replicating in the nose would lessen transmission.
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