Key to the findings is that T-cells are far from the only immune cells capable of taking the fight to cancer, with researchers finding the TLS were full of B-cells, a kind of immune cell. — Ugreen/Istock.com pic via AFP
The technique has largely focused on white blood cells called T-cells, which are “trained” to recognise and attack cancer cells. “The cells need to be educated in schools, which are the tertiary lymphoid structures,” where they effectively learn to recognise and attack cancer cells, Fridman told AFP.Key to the findings is that T-cells are far from the only immune cells capable of taking the fight to cancer, with researchers finding the TLS were full of B-cells, a kind of immune cell that produces antibodies.“We analysed these sarcomas to see what groups they had and what's striking is that these B-cells appeared.
The discovery is something of a surprise, as an abundance of B-cells in cancer patients has sometimes been seen as a marker for poor prognosis. The work “could be used to improve the effectiveness of cancer immunotherapy for all patients,” he said.Scientists are not yet sure why the structures form in some tumours and not others.
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