The agency's advice is in line with the so-called fractional dosing approach endorsed by U.S. regulators in which one vial of the vaccine can be used to administer up to five separate doses - instead of a single dose - by injecting a smaller amount in between layers of the skin .
As a temporary measure, national authorities may decide to use the vaccine as an intradermal injection at a lower dose to protect at-risk individuals during the current monkeypox outbreak while supply of the vaccine remains limited, the EMA said. Those who received the intradermal injection received one fifth of the subcutaneous dose, but produced similar levels of antibodies as those who received the original subcutaneous dose, the EMA said.
More than 40,000 confirmed cases of monkeypox - including a handful of deaths - in over 80 countries where the virus is not endemic have been reported since early May.
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