Jesus, who has recently come back from injury, and scored in City's 1-1 draw with Liverpool on Sunday, will now fly to South America to take part in World Cup qualifiers with Brazil.
"That is the challenge for me, keep fit and don't get injured because this season is going to be dangerous for players because too many games." Klopp has been vocal in his criticism of the Premier League's decision not to stick with last year's temporary rule allowing five instead of three substitutions.
City manager Pep Guardiola said he had talked about the issue at the end of the game after the champions' right back Trent Alexander-Arnold suffered an injury.
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