It already seems strange that the first weapons immediately to hand in fighting a new viral disease would be an antimalarial and an antibiotic , but there were decent reasons to think either or both might be effective. In “in vitro” lab studies, azithromycin does seem to squash some kinds of viruses, and it was quickly confirmed that our friend SARS-CoV-2 is one of these. In general it also has desirable effects on the immune system and seems to be good for the lungs.
It was hydroxychloroquine that attracted the attention of researchers first, partly for weird political reasons that the future will have trouble understanding, and it hasn’t had a good run. After plenty of study, no evidence has emerged that it helps anybody in a scientifically observable or reproducible way.
There’s a problem with the study, in that everybody in it was still receiving hydrochloroquine for lack of a superior standard of care. As an accompanying editorial in the Lancet notes, it now seems “unlikely that hydroxychloroquine has any effect on disease progression,” but its use might still, in principle, be interfering with the effect of azithromycin.
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