'We could eradicate malaria by 2040' says expert after revolutionary vaccine is approved by WHO

The World Health Organization has approved a new vaccine that scientists argue will be a game-changer in the fight against malaria, which kills half a million people in Africa every year. Trials have shown that the R21/Matrix vaccine, developed by Oxford University together with the Serum Institute of India, reduces malaria by up to 75%. It can be manufactured cheaply and on a mass scale.

The Serum Institute of India, our manufacturing and commercial partner, can produce hundreds of millions of doses of this vaccine each year, whereas the previous vaccine could be manufactured at a scale of six million doses a year from 2023 to 2026, according to Unicef reports. Malaria is not a virus, it’s not a bacterium. It’s a protozoan parasite, some thousands of times larger than a typical virus. A good measure of that is how many genes it has. Covid has 13, malaria has about 5,500. This is one of the reasons that malaria is super complex.

We’ve been working on targeting the so-called sporozoites, which is the form that the mosquito inoculates into your skin. We’re trying to trap it before it can get to the liver and carry on the life cycle. It wasn’t until the 1980s when we could actually begin to sequence the genes in the parasite that new vaccination candidates appeared. And then within 10 years we had 5,000 candidates because everyone hoped that the gene they had sequenced might be a malaria vaccine. And of course almost all of those failed.

Source: Healthcare Press (healthcarepress.net)

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