Composite: Dawicki-McKenna JM, Langelier MF, Denizio JEComposite: Dawicki-McKenna JM, Langelier MF, Denizio JESue Hayward was first diagnosed with ovarian cancer in 2017. Doctors acted swiftly and she was given a hysterectomy followed by sessions of chemotherapy.
“Effectively, Parp inhibitors would be used as a preventive medicine to stop certain tumours from ever appearing,” said Professor Herbie Newell, of Newcastle University. “We will have moved the battle against cancer on to a new footing.” The clinical evaluation of the first Parp inhibitors began 20 years ago just as the funding charity Cancer Research UK was formed out of an amalgamation of the Imperial Cancer Research Fund and the Cancer Research Campaign. Since then the organisation has played a key role in funding research in the field.“Essentially we have found the achilles heel of tumour cells and have learned how to use that information to destroy them,” said cancer expert Prof Steve Jackson of Cambridge University.
“When we first developed Parp inhibitors we gave them to patients who were in the late stages of their cancers,” said Jackson. “They had nothing to lose. We were not sure what to expect but found there were quite a number of patients who responded quite profoundly.”
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