HRT ‘potentially important’ in reducing women’s dementia risk

Hormone replacement therapy may help prevent Alzheimer’s disease in millions of women at risk of developing the condition, research suggests.

Although they stressed they could not say for sure that HRT cut the risk in women, the findings were “really important” amid limited drug options for dementia and an urgent need for novel treatments. In the study, researchers found that HRT was most effective when given during perimenopause – where symptoms build up months or years before periods stop – and could lead to brains that appear several years younger.

The results showed that APOE4 carriers who also used HRT had better cognition and higher brain volumes than people not on HRT and non-APOE4 carriers. The risk of Alzheimer’s and other types of dementia increases with age, affecting an estimated one in 14 people over the age of 65 and one in every six over the age of 80. Inheriting APOE4 does not mean someone will definitely develop the condition.

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