Experimental Alzheimer’s drug slows cognitive decline in trial, firms say

An experimental Alzheimer’s drug slowed cognitive and functional decline by 27 per cent in a closely watched clinical trial, the sponsors of the medication said Wednesday, increasing the therapy’s chance for approval as soon as early next year.

Like Aduhelm, lecanemab reduces abnormal clumps of beta amyloid, a hallmark of Alzheimer’s. But unlike Aduhelm, for which the data was confused and conflicting, the trial results for lecanemab told a straightforward and encouraging story, some experts said. Aduhelm was approved by the Food and Drug Administration, but Medicare refused to cover it broadly, and the drug collapsed in the marketplace.

Some other experts cautioned that the benefits of the drug were likely to be small and said they wanted to see the full data before reaching conclusions. Officials said the clinical trial participants were tested in several areas to gauge the pace of their decline, including memory, orientation and problem solving. Starting at six months, the companies said, the group that received the treatment did better than the placebo group. The treatment was administered intravenously twice a month.

Source: Law Daily Report (lawdailyreport.net)

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