Most mammals, including humans, have two sex chromosomes, X and Y. One sex chromosome is usually inherited from each parent, and they pair up as either XX or XY in every cell of the body.
Female calico cats almost always have orange and black splotches of fur, because the gene that defines coat color is found on the X chromosome.
For this reason, male cats, which typically have one X and one Y chromosome, have solid orange or black coats.
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