Scientists in California tested a way to coax certain fat cells to burn calories, rather than simply store energy. In new research involving mice, the team found it was possible to convert existing white fat cells into calorie-burning beige fat cells. The findings could pave the way to a new class of obesity treatments, the study authors say. Scientists at the University of California San Francisco were trying to get to the root of a problem that has long stymied others in the field.
In this latest study, published in the Journal of Clinical Investigation, the UCSF team say they have landed on a new promising approach. Working with mice, the group had earlier found evidence that a protein called KLF-15 was important to the distinction between white and beige/brown fat cells. In their mice, KLF-15 was much more present in brown and beige fat cells compared to white fat cells. So they decided to breed mice whose white fat cells lacked KLF-15 entirely.
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