Sickle cell disease is the most common blood disorder passed down from parents to children. Learn how a gene mutation causes it.
About 100,000 people in the United States have sickle cell disease. Most of them are African American.Babies born with SCD usually show symptoms at around 5 months of age. Symptoms vary from person to person and change over time. Symptoms can include:. Sickle cells are more fragile than normal red blood cells and tend to die in 10-20 days. Normal cells live for about 120 days. This causes a shortage of red blood cells, known as anemia.
Both your parents need to pass the abnormal hemoglobin gene on to you in order for you to develop the disease. If both your parents carry the defective gene, you have a 1 in 4 chance of inheriting the disease and becoming sick with it.of the disease. Carriers usually don’t develop SCD symptoms. But they can pass the disease on to their children if their partner also carries the sickle cell trait.In the United States, SCD affects African American people more than other races.
SCD also affects people from Hispanic, southern European, Middle Eastern, and Asian Indian backgrounds.There are several forms of sickle cell disease. The type you or your child inherits depends on many things, including the specific type of abnormal hemoglobin you have.Other common forms include:
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