Taking sulfonylureas sold as 'street Valium' can lead to severe hypoglycemia that may result in emergency department visits, the latest of a handful of case reports suggests. AACE2023
presented at the 2022 Endocrine Society meeting, sulfonylurea had been cut with cocaine, presumably to increase the volume.
Laboratory results showed elevations in levels of insulin , C-peptide , and glucose . He was again treated with D50W, and his blood glucose level returned to normal over 20 hours. Once alert and oriented, he reported no personal or family history of diabetes. A 72-hour fast showed no evidence of insulinoma. A sulfonylurea screen was positive for glyburide. He was discharged home in stable condition.
"The management of sulfonylurea overdose includes administration of glucose but also may include the use of octreotide, a unique antidote for sulfonylurea induced hypoglycemia," Smollin told Medscape.
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