Second-generation basal insulins improved the glycemic parameters in patients with type 2 diabetes when added to or used as a substitute for GLP-1 therapy.
In patients with type 2 diabetes on first-line glucagon-like peptide 1 receptor agonist therapy, adding or switching to second-generation basal insulins may greatly improve A1c and fasting blood glucose compared with first-generation basal insulins.
Between 2011 and 2021, the patients received basal insulin as either an add-on to or a switch from an ongoing GLP-1 therapy.In the ADD-on cohort, between added first-generation basal insulins and added 2BI .In the SWITCH 2BI group, between those switched to Gla-300 or to Deg-100. Propensity score matching was performed, and changes in A1c, FBG levels, and body weight at baseline and at 6 months were assessed.In the ADD-ON cohort, after 6 months, those on 2BI showed greater improvement in A1c than those on first-generation basal insulin.=.03), a 10.15-mg/dL reduction in FBG (Among those switched to 2BI, Gla-300 showed a significant improvement over Deg-100, with a 0.
Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D Attention Deficit Disorder ADD - Attention Deficit Disorder ADD ADHD Attention Deficit Hyperactivity Disorder Attention Deficit Hyperactivity Disorder (ADHD) Metabolism Metabolic GLP-1 Receptor Agonists Glucagon-Like Peptide-1 Receptor Agonists Blood Board Certification Boards
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