Scientists at The Hospital for Sick Children and the University of Toronto have combined forces to develop a new approach to potentially treat tumor cells, called mechanical nanosurgery, even for aggressive, chemoresistant cancers.
The current global standard-of-care treatment for GBM patients includes chemotherapy using a drug called temozolomide , which extends a person’s life expectancy by approximately two months compared to patients receiving radiotherapy alone. However, GBM cells can develop resistance to TMZ over time, reducing its efficacy and increasing the likelihood of tumor relapse., Dr. Xi Huang, a Senior Scientist in the Developmental & Stem Cell Biology program at SickKids, and Dr.
“Through the use of nanotechnology deep inside cancer cells, mechanical nanosurgery is a ‘Trojan Horse’ approach that could allow us to destroy tumor cells from within,” says Huang, whose previous research demonstrating that brain tumor cells are mechanosensitive helped to inform the approach. “By combining our expertise in biochemistry at SickKids and engineering at U of T, we’ve developed a potential new way to treat aggressive brain cancer.
“Once the nanotubes are inside the tumor cell, we use a rotating magnetic field to mechanically mobilize the nanotubes to provide mechanical stimulation,” says Sun. “The force exerted by the nanotubes damages cellular structures and cause tumor cell death.”Huang’s partnership with Sun at the U of T Department of Mechanical Engineering is continuing to build on the study findings.
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