By Brian Gormley Sept. 15, 2019 10:04 pm ET Scientists are pursuing the first medicines to treat hearing loss.
World-wide, 466 million people have disabling hearing loss, including 34 million children, according to the World Health Organization. Children with severe to total hearing loss have lower literacy than their fully hearing peers, and their education is greatly compromised, according to a 2017 paper in the medical journal Lancet.
The company hopes a one-time treatment will let children with this rare disorder hear without a cochlear implant. Clinical trials are expected to begin in 2021, says Dr. Simons, adding. “Our hope is we might be able to restore true physiologic hearing that is very close to normal.” A synthetic virus carrying a healthy copy of the otoferlin gene is injected into an ear structure known as the round window.The fluid the virus is delivered into comes into contact with sensory hair cells in the inner ear that are required for hearing.hair cellSensory hair cells, equipped with the normal otoferlin gene, can now perform their job of transmitting sound vibrations that they convert into electrical signals to the brain.“This has some real promise,” Dr. Lustig says.
For children, “If Decibel Therapeutics could pair up with a company that has a better way of delivering what they have into the inner ear, I think they could do very well,” Dr. Chang says. Birds, fish, reptiles and amphibians spontaneously regenerate hair cells, but not humans, says Robert Jackler, chairman of the department of otolaryngology-head and neck surgery at Stanford University School of Medicine.
Well, that’ll be one time in a row...
According to the wife I have selective hearing...any cure for that?
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