Nature research paper: cGAS–STING drives ageing-related inflammation and neurodegeneration
) mice, tamoxifen was intraperitoneally injected into 8–10-week-old mice once every 24 h on 5 consecutive days. Some mice also received 750 nmol H-151 daily, starting with tamoxifen injections. Within 1 week after the last administration of tamoxifen, some mice were analysed using cognitive tests and euthanized for tissue analysis.
To test the in vivo specificity of H-151, mice received 15 mg per kg of a STING agonist intraperitoneally. H-151 was administered to one group 30 min before the injection of the STING agonist and, 3 h later, the mice were euthanized for tissue collection. The cages were kept at 18–24 °C ambient temperature under 40–60% humidity. The mice were maintained under a 12 h–12 h light–dark cycle from 06:00 to 18:00. Food and water were available ad libitum. Mice were euthanized by anaesthetization by an injection of an overdose of sodium pentobarbital .
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